Nerve Growth Factor-Inducing Activity of Hericium Erinaceus (PDF)

Medicinal Uses of Hericium Erinaceus (PDF)

The Hericium Erinaceum Juice

Hericium Erinaceum (猴头菇）

Hericium erinaceum is an edible mushroom, and its fruiting bodies have been used for the treatment of dyspepsia, gastric ulcer and enervation as a Chinese medicine in China.

Recently, Hericium erinaceum has been reported to show antitumor action and antidiabetic activity. Also, hericenones and erinacines, which were isolated from Hericium erinaceum, have potent stimulating activity for nerve-growth factor (NGF) synthesis.

Moreover, Hericium erinaceum has antioxidant properties and reduce platelet aggregation. In the present study, reseachers in Japan investigated the neuroprotective effect of Hericium erinaceum on the ischemic brain damage in a middle cerebral artery occulusion (MCAO) model in mice. Hericium erinaceum (300 mg/kg, continuous 14-day p.o.) significantly decreased the size of the cerebral infarcts 1 day after the occulusion (4 h). These results suggest that Hericium erinaceum provides neuroprotection against focal cerebral ischemia and may be clinically useful for preventing cerebral infarction.

Research summaries:

Effect of Hougujun Tablets on DNA, Bcl-2 Content of Gastric Premalignant Lesion

GAO Ze-li1，AN Shu-hua2，WU Min-sheng1，ZHOU Lian-fu2，NI Li ng-mei1，TAO Feng-ying1

(1. Department of digestion, Yangpu central hospital, Shanghai 200090， China; 2. Hebei Provincial cancer Research Institute, Shijiazhuang 050017, China)

Abstract：

Objective：To select the effective drug for treating gastric premalignant lesion and to observe the effect of Hougujun Tablets on D NA, Bcl-2 content of gastric premalignant lesion.
Methods： 20 cases of chronic atrophy gastritis (CAG) with intestinal metaplasia (IM); 20 cases CAG with dysplasia (DYS) were treated with Houtoujun Tablets for 6 months. The morphological comparison observation and DNA, Bcl-2 content analysis before and after treatment were performed.
Results：After treatment, 12 cases showed IM disappear among 20 cases CAG with IM, 8 cases showed DYS disappear among 20 cases CAG with DYS. The gastric premalignant lesion Fluorescence index (FI) of Bcl-2 protein decreased. There was a significant difference in FI positive rate between before and after treatment.
Conclusion：Hougujun Tablet has a therapeutic effect on the gastric premalignant lesion.

Key words： Hougujun Tablet； precancerous lesion; gastric neo plasm; cytometry

猴菇多糖对胃癌癌前病变的逆转治疗研究

高泽立1，安淑华2，吴敏生１，左连富2，倪林妹1，陶风英1
(1. 上海市杨浦区中心医院消化科，上海 200090； 2. 河北省肿瘤研究所，河北 石家庄 050017)

摘要：
目的：为筛选治疗胃癌前病变及早期胃癌的有效药物，应用猴菇多糖施以胃癌癌前病变患者。
方法：慢性萎缩性胃炎(Chronic Atrophy Gastritis, CAG)伴肠上皮化生(Intestinal metaplasia, IM)20例，CAG伴异型增生(Dysplasia, DYS)患者20例。疗程6个月后进行治疗前后形态学对比观察，并进行DNA含量分析及B Cell Lymphosarcomo-2(Bcl-2),蛋白含量测定。
结果：治疗后20例CAG伴IM组12例肠上皮化生消失，20例CAG伴DYS组8例异型增生消失；Bcl-2表达量(荧光指数FI)减少，治疗前后FI阳性率有显著差异(P<0.05)。
结论：猴菇多糖对胃癌癌前病变有较好的临床疗效。

关键词：猴头菌片；胃肿瘤；癌前病变；流式细胞光度术

中图分类号：R573.3+2 文献标识码：A 文章编号：1001-1528(2000)08-0555-04

© Copyright 2002 by Hirokazu Kawagishi,1 Ph.D., Shoei Furukawa,2 Ph.D., Cun Zhuang,3 Ph.D., and Rika Yunoki 4; Japan & USA (Explore Issue: Volume 11, Number 4)*

Abstract

Nerve growth factor (NGF) is closely related to Alzheimer's dementia, and studies have suggested that the disease may be prevented or its symptoms may be improved when NGF is given into the brain directly. However, since NGF is a protein it usually cannot pass through the blood-brain barrier. Recently, researchers have targeted on the substances that could pass through the blood-brain barrier and induce NGF synthesis in the brain. Some compounds with lower molecular weight have been found to have such bioactivity. Among these bioactive compounds, hericenones and erinacines, which were isolated from an edible mushroom called as Lion's Mane (Hericium erinaceum), showed remarkable activity of stimulating the synthesis of NGF. They could be developed as a dietary supplement or medicine to be used for treating Alzheimer's dementia. This article offers an introduction to the isolation method, bioactivity assay and chemical structure analysis of hericenones and erinacines.

关于由猴头菇(Hericium erinaceum)
导致神经生长因子合成的论述

总论：发现和分离出生长因子(for the discoveries of growth factors)就是一项伟大的工作。为此，两名科学家：美国的斯坦利•科恩（Stanley Cohen）和美籍意大利裔的丽塔•莱维-蒙塔尔齐尼(Rita Levi - Montalcini )分享了1986年度的诺贝尔医学奖 (The Nobel Prize in Physiology or Medicine 1986) 。而发现猴头菇中的活性物质可以诱导生成神经生长因子（Nerve Growth Factor-NGF）则更是一项伟大和艰巨的任务。

论文摘录

神经生长因子(NGF)与阿尔茨海默氏（Alzheimer）痴呆症紧密相关, 该研究指出, 当把神经生长因子直接输入大脑时，可以预防该疾病和改善其症状。研究发现,由于神经生长因子的分子量较高，使它无法通过血-脑屏障(blood-brain barrier)进入大脑。而,研究人员在猴头菇中找到了两种物质，它们具有较低分子量和生物活性，可以自由地通过血-脑屏障，同时在大脑中促使神经生长因子的合成。这种低分子量和具有生物活性的化合物被称为猴头菇酮（hericenones）和猴头菇素（erinacines）。它们是从猴头菇(Hericium erinaceum)中分离出来的。根据它们的这种作用，猴头菇可用来开发针对阿尔茨海默氏痴呆症等病状的饮食补充物或药品。此文章描述了猴头菇酮和猴头菇素的分离方法, 生物活性及其化学结构。

关键字：神经生长因子(NGF)，血-脑屏障(blood-brain barrier)，猴头菇酮（hericenones），猴头菇素（erinacines）
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*访问下面的网页阅读全文（Read paper to visit the next URL）http://www.explorepub.com/articles/kawagishi_11_4.html

Neuroprotective Effect of Hericium erinaceum.
Michihiro Fujiwara, Nobuaki Egashira, Kenichi Mishima. Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University. 8-19-1, Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan

Summary:
Hericium erinaceum is an edible mushroom, and its fruiting bodies have been used for the treatment of dyspepsia, gastric ulcer and enervation as a Chinese medicine in China. Recently, Hericium erinaceum has been reported to show anti-tumor action and anti-diabetic activity. Also, hericenones and erinacines, which were isolated from Hericium erinaceum, have potent stimulating activity for nerve-growth factor (NGF) synthesis. Moreover, Hericium erinaceum has antioxidant properties and reduce platelet aggregation. In the present study, we investigated the neuroprotective effect of Hericium erinaceum on the ischemic brain damage in a middle cerebral artery occulusion (MCAO) model in mice. Hericium erinaceum (300 mg/kg, continuous 14- day p.o.) significantly decreased the size of the cerebral infarcts 1 day after the occulusion (4 h). These results suggest that Hericium erinaceum provides neuroprotection against focal cerebral ischemia and may be clinically useful for preventing cerebral infarction.