IMMUNO CPX™

 

PRODUCT DESCRIPTION

Immuno CPX is a supplement developed by Taiwan Medical University in collaboration with Japan Genetic Research Institute. It is used as an adjuvant therapy for people receiving chemotherapy, surgery and/or radiation therapy. It modulates immunity, enhances the efficacy of chemotherapy, and helps alleviate post-chemotherapy symptoms.

Antrodia camphorata (syn. Antrodia cinnamomea, Taiwanofungus camphorata) is an indigenous and rare mushroom that possesses a number of bioactive properties suchas anti-cancer, antioxidant, anti-inflammatory, anti-hypertensive,anti-hepatitis B virus replication, hepatoprotective and neuroprotective functions.1-8

A. camphorata is able to provide a radioprotective effect to immune cells and enhances radiation-induced inflammation and cytotoxicity in cancer cells.9 In addition, A. camphorata showed enhanced cytotoxicity when it is used in combination with other agents such as paclitaxel, trichostatin A (TSA) and lovastatin.10-12 This synergistic effect suggest the potential for its use as an adjuvant to chemotherapy. The anti-cancer activity of A. camphorata works via modulating multiple signaling pathways at various cellular levels, resulting in apoptosis, call cycle arrest, growth inhibition, anti-angiogenesis and inhibition of metastasis.

Coriolus versicolor is a mushroom belonging to the species of the Homobasidiomycetes class, Polyporaceae family. Its immunity enhancing and anti-tumor properties enable its use as a valuable adjuvant for combination chemotherapy or radiotherapy in the treatment of various cancers in China and Japan.13Among various bioactive components derived from C. versicolor, polysaccharopeptide (PSP), a protein-bound polysaccharide isolated from the deep-layer cultivated mycelia of C. versicolor, is found to have the most prominent anti-tumor and immunomodulatory activity.Studies have shown that PSP stimulated the production of interferon-ɣ and interleukin-2, increased T-cell proliferation, and dose-dependently inhibited the proliferation of leukemia, lymphoma and hepatoma cell lines in vitro.14-19

Curcumin is the active component of dried rhizome of turmeric (Curcuma longa), a perennial herb cultivated extensively in south and southeastern tropical Asia.20 Curcumin has been extensively researched over decades, with numerous reports of its antioxidant, anti-inflammatory, hepatoprotective, chemoprotective and anti-carcinogenic properties.20-26 It works by suppressing proliferation and metastasis of human tumors through regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases and other enzymes. It inhibits proliferation of cancer cells by cell cycle arrest and induces apoptotic cell death.27-28Curcumin has been reported to inhibit various stages of carcinogenesis in various cancer types, including colorectal, pancreatic, gastric, prostate, hepatic, breast, oral cancers, and leukemia.29

Phellinus linteus, a species of mushroom belonging to Hymenochaetaceae family, is rich in nutrients including saccharides, proteins, vitamins, minerals and large amounts of β-glucan.30-31 It has been widely used for millennia in Korean, China and Japan as an ancient herbal medicine as it possesses various biological activities, such as antioxidative,anti-inflammatory, anti-viral and anti-cancer effects.32-39

SUPPLEMENT FACTS

Amount per serving	3g x 30 sachets / box
Ingredients	Antrodia camphorata mycelia 1.35g Phellinus linteus mycelia 1.05g Polysaccharide-peptide (PSP) of Coriolus versicolour 0.30g Turmeric root extract (Curcuma longa) 0.30g
Administration	Take before sleep Take before or after meal
Caution for use	Infant, pregnant & lactation, please consult doctor before use
Storage	Store in a cool, dry place. Protect from light.

REFERENSI

1. Hseu YC, Chen SC, Yech YJ, Wang L, Yang HL. Antioxidant activity of Antrodia camphorata on free radical-induced endothelial cell damage. J Ethnopharmacol. 2008 Jul 23;118(2):237-45.
2. Chen JJ, Lin WJ, Liao CH, Shieh PC. Anti-inflammatory benzenoids from Antrodia camphorata. J Nat Prod. 2007 Jun;70(6):989-92.
3. Lee TH, Lee CK, Tsou WL, Liu SY, Kuo MT, Wen WC. . A new cytotoxic agent from solid-state fermentedmycelium of Antrodia camphorata. Planta Med. 2007 Oct;73(13):1412-5.
4. Lu ZM, Tao WY, Zou XL, Fu HZ, Ao ZH. . Protective effects of mycelia of Antrodia camphorata and Armillariella tabescens in submerged culture against ethanol-induced hepatic toxicity in rats. J Ethnopharmacol. 2007 Mar 1;110(1):160-4.
5. Chang CY, Huang ZN, Yu HH, Chang LH, Li SL, Chen YP, Lee KY, Chuu JJ. The adjuvant effects of Antrodia camphorata extracts combined with anti-tumor agents on multidrug resistant human hepatoma cells. J Ethnopharmacol. 2008 Aug 13;118(3):387-95
6. Wang GJ, Tseng HW, Chou CJ, Tsai TH, Chen CT, Lu MK. The vasorelaxation of Antrodiacamphoratamycelia: involvement of endothelial Ca2+-NO-cGMP pathway. Life Sci. 2003 Oct 10;73(21):2769-83.
7. Lu MK, Cheng JJ, Lai WL, Lin YJ, Huang NK. FermentedAntrodia cinnamomea extract protects rat PC12 cells from serum deprivation-induced apoptosis: the role of the MAPK family. J Agric Food Chem. 2008 Feb 13;56(3):865-74.
8. Chen YJ, Cheng PC, Lin CN, Liao HF, Chen YY, Chen CC, Lee KM. Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni. Int Immunopharmacol. 2008 Mar;8(3):458-67
9. Cheng PC, Huang CC, Chiang PF, Lin CN, Li LL, Lee TW, Lin B, Chen IC, Chang KW, Fan CK, Luo TY. Radioprotective effects of Antrodia cinnamomea are enhanced on immune cells and inhibited on cancer cells. Int J Radiat Biol. 2014 Oct;90(10):841-52.
10. Lu MC, Du YC, Chuu JJ, Hwang SL, Hsieh PC, Hung CS, Chang FR, et al. Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A. Arch Toxicol 2009;83:121e9.
11. Liu SY, Wen WC, Tsou WL, Kuo MT. Compound from Antrodia camphorata for inhibiting the growth of cancer cells. US Patent 2008/0103195. 2008.
12. Yao CJ, Chuang SE, Lai GM, Chan CF. Cancer treatment. US Patent 2009/0196885. 2009.
13. Eliza WL, Fai CK, Chung LP. Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis. Recent Pat Inflamm Allergy Drug Discov. 2012 Jan;6(1):78-87.
14. Ho CY, Kim CF, Leung KN, Fung KP, Tse TF, Chan H, Lau CB. Coriolus versicolor (Yunzhi) extract attenuates growth of human leukemia xenografts and induces apoptosis through the mitochondrial pathway. Oncol Rep. 2006 Sep;16(3):609-16.
15. Wang HX, Ng TB, Liu WK, Ooi VE and Chang ST: Polysaccharide-peptide complexes from the cultured mycelia of the mushroom Coriolus versicolor and their culture medium activate mouse lymphocytes and macrophages. Int J Biochem Cell Biol 28: 601-607, 1996.
16. Chow LW, Lo CS, Loo WT, Hu XC and Sham JS: Polysaccharide peptide mediates apoptosis by up-regulating p21 gene and down-regulating cyclin D1 gene. Am J Chin Med 31: 1-9, 2003.
17. Dong Y, Yang MP and Kwan CY: In vitro inhibition of proliferation of HL-60 cells by tetrandrine and Coriolus versicolor peptide derived from Chinese medicinal herbs. Life Sci 60:135-140, 1997.
18. Hsieh TC, Kunicki J, Darzynkiewicz Z and Wu JM: Effects of extracts of Coriolus versicolor (I’m-Yunity) on cell-cycle progression and expression of interleukins-1 beta, -6 and -8 in promyelocytic HL-60 leukemic cells and mitogenically stimulated and non-stimulated human lymphocytes. J Altern Complement Med 8: 591-602, 2002.
19. Qian ZM, Xu MF and Tang PL: Polysaccharide peptide (PSP) restores immunosuppression induced by cyclophosphamide in rats. Am J Chin Med 25: 27-35, 1997.
20. Vyas A, Dandawate P, Padhye S, Ahmad A, Sarkar F. Perspectives on new synthetic curcumin analogs and their potential anticancer properties. Curr Pharm Des. 2013;19(11):2047-69.
21. Sreejayan, Rao MN. Nitric oxide scavenging by curcuminoids. J Pharm Pharmacol. 1997 Jan;49(1):105-7.
22. Brouet I, Ohshima H. Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase inactivated macrophages. Biochem Biophys Res Commun. 1995 Jan 17;206(2):533-40.
23. Kiso Y, Suzuki Y, Watanabe N, Oshima Y, Hikino H. Antihepatotoxic principles of Curcuma longa rhizomes. Planta Med. 1983 Nov;49(3):185-7.
24. Chen A, Xu J, Johnson AC. Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1. Oncogene. 2006 Jan 12;25(2):278-87.
25. Chen J, Tang XQ, Zhi JL, Cui Y, Yu HM, Tang EH, Sun SN, Feng JQ, Chen PX. Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway. Apoptosis. 2006 Jun;11(6):943-53.
26. Divya CS, Pillai MR.Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NFkB and AP-1 translocation, and modulation of apoptosis. Mol Carcinog. 2006 May;45(5):320-32.
27. Shishodia S, Singh T, Chaturvedi MM. Modulation of transcription factors by curcumin. Adv Exp Med Biol. 2007;595:127-48.
28. Aggarwal S, Takada Y, Singh S, Myers JN, Aggarwal BB.Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling. Int J Cancer. 2004; 111:679–92.
29. Aggarwal BB, Kumar A, Bharti AC. Anticancer Potential of Curcumin: Preclinical and Clinical Studies. Anticancer Res. 2003 Jan-Feb;23(1A):363-98.
30. Sliva D. Medicinal mushroom Phellinus linteus as an alternative cancer therapy. Exp Ther Med 2010;1:407-11.
31. Kim HM, Han SB, Oh GT, Kim YH, Hong DH, Hong ND, Yoo ID. Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus. Int J Immunopharmacol 1996;18:295-303.
32. Lee IK, Yun BS. Highly oxygenated and unsaturated metabolites providing a diversity of hispidin class antioxidants in the medicinal mushrooms Inonotus and Phellinus. Bioorg Med Chem 2007;15:3309-14.
33. Yeo WH, Hwang EI, So SH, Lee SM. Phellinone, a new furanone derivative from the Phellinus linteus KT&G PL-2. Arch Pharm Res 2007;30:924-6.
34. Lee IK, Yun BS. Styrylpyrone-class compounds from medicinal fungi Phellinus and Inonotus spp., and their medicinal importance. J Antibiot (Tokyo) 2011;64:349-59.
35. Zheng YB, Lu CH, Shen YM. New abscisic acid-related metabolites from Phellinus vaninii. J Asian Nat Prod Res 2012;14:613-7.
36. Yeom JH, Lee IK, Ki DW, Lee MS, Seok SJ, Yun BS. Neuraminidase inhibitors from the culture broth of Phellinus linteus. Mycobiology 2012;40:142-4.
37. Lee IK, Han MS, Lee MS, Kim YS, Yun BS. Styrylpyrones from the medicinal fungus Phellinus baumii and their antioxidant properties. Bioorg Med Chem Lett 2010;20:5459-61.
38. Kim HG, Yoon DH, Lee WH, Han SK, Shrestha B, Kim CH, Lim MH, Chang W, Lim S, Choi S, et al. Phellinus linteus inhibits inflammatory mediators by suppressing redox-based NF-kappaB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophage. J Ethnopharmacol 2007;114:307-15.
39. Ichinohe T, Ainai A, Nakamura T, Akiyama Y, Maeyama J, Odagiri T, Tashiro M, Takahashi H, Sawa H, Tamura S, et al. Induction of cross-protective immunity against influenza A virus H5N1 by an intranasal vaccine with extracts of mushroom mycelia. J Med Virol 2010;82:128-37.

 

 

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To order or to ask a question:

Nutrimax Wellness Store, Singapore
390 Victoria St #02-30 Golden Landmark (Opp. Raffles Hospital) Singapore 188061 Tel: 6292 2991, 83338375 (Mobile)